Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.

Originally Published in The Scientist, November 16th, 2020

The mysteries of a salamander regenerating its tail or a sea cucumber mending its organs have fascinated humans and perplexed scientists for centuries. The idea that the human body holds similar mechanisms to heal and repair itself is tantalizing and not altogether impossible. There are powerful cells called mesenchymal stem cells situated on the 50,000–100,000 miles of blood vessels in the human body. These cells carry the ability to initiate signaling cascades that drive tissue repair and regeneration.

In the mid-1960s, Marshall Urist, an orthopedic surgeon at the University of California Center…


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Welcome to Spencer Trask Perspectives, a monthly interview series with our CEO Bill Clifford and writer John Essick. In each installment, Mr. Clifford shares his unique insights and expert opinions on topics such as business development, deal flow, C-suite management, startup culture, entrepreneurialism, and more.

We welcome your feedback, and encourage you to submit questions to askST@spencertraskco.com for Mr. Clifford to answer in future articles.

Since February of 2020, COVID-19 has been disrupting sectors and industries across the board. As of November 1st, 556 corporations have filed for bankruptcy, according to S&P Global Market Intelligence. We have watched Wall Street…


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Welcome to Spencer Trask Perspectives, a monthly interview series with our CEO Bill Clifford and writer John Essick. In each installment, Mr. Clifford shares his unique insights and expert opinions on topics such as business development, deal flow, C-suite management, startup culture, entrepreneurialism, and more.

We welcome your feedback, and encourage you to submit questions to askST@spencertraskco.com for Mr. Clifford to answer in future articles.

The past few months have been filled with stories of small businesses struggling to survive, or even worse, shutting down completely. …


Early trials show signaling cells eliminate the virus, calm the immune response and repair tissue damage.

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By Kevin Kimberlin

Originally Published in The Wall Street Journal, August 13th, 2020

More than 500 clinical trials are under way world-wide in the race to find an effective treatment for COVID-19. Everybody wants it; nobody has it — yet. But one of the most promising therapies for COVID-19 patients uses “medicinal signaling cells,” or MSCs, which are found on blood vessels throughout the body.

In preliminary studies, these cells cut the death rate significantly, particularly in the sickest patients. With a powerful 1–2–3 punch, these cells eliminate the virus, calm the immune overreaction known as a cytokine storm, and…


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Top scientists are confirming our fears: COVID-19 will not be going away anytime soon. Unfortunately, the “post-COVID-19” work culture does not exist, and as we have heard many times before, we are officially entering a new normal. This new normal has presented business leadership with new and unfamiliar challenges, chief among them will be attracting and retaining talent in what has become a much more virtual workforce.

How can employers embrace the New Workforce, and stay competitive in attracting and maintaining their employees?

The Virtual Workplace Emerges It is rather remarkable the way that many businesses quickly adapted to keep…


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Welcome to Spencer Trask Perspectives, a monthly interview series with our CEO Bill Clifford and writer John Essick. In each installment, Mr. Clifford shares his unique insights and expert opinions on topics such as business development, deal flow, C-suite management, startup culture, entrepreneurialism, and more.

We welcome your feedback, and encourage you to submit questions to askST@spencertraskco.com for Mr. Clifford to answer in future articles.

Every economic downturn bears its own unique burdens, but one thing is common to all, businesses are forced to respond to unexpected challenges. While the disruptions we are experiencing during the COVID-19 economy may be…


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Welcome to Spencer Trask Perspectives, a monthly interview series with our CEO Bill Clifford and writer John Essick. Mr. Clifford has generously agreed to share his unique insights and expert opinions on topics such as business development, deal flow, C-suite management, startup culture, entrepreneurialism, and more.

We welcome your feedback, and encourage you to submit questions to askST@spencertraskco.com for Mr. Clifford to answer in future articles.

No one really knows what to expect the business environment to look like after the world emerges from the COVID-19 virus outbreak. This is especially true for new companies looking for funding, or startups…


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A company like Interos did not become the leading supply chain assessment company in the world overnight. It required visionary leadership, like that provided by the company’s CEO Jennifer Bisceglie, and an investment in ideas by Spencer Trask & Co. that led to Trensant’s artificial intelligence (AI) platform that provides actionable insights to Interos’ clients by processing massive amounts of data. As a result, some of the largest banks, airlines, manufacturing companies and U.S. government agencies receive real-time analysis of more than 85,000 data feeds to identify supply chain risks in our intertwined global marketplace.

The Trensant AI Platform Drives…


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By Bill Clifford

The COVID-19 virus has caused offices around the nation to shut down all but essential businesses, forcing startups and early stage CEOs/entrepreneurs to face the daunting task of managing a workforce that they have hardly had the chance to know — much less grow into a cohesive, well-oiled group of tightly knit workers. In many cases these new CEO/entrepreneurs are new to the task of executive management.

Many of the office closures we are seeing across the nation at the moment are mandated by the need to protect workers from the spread of the COVID-19 virus. However…


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Welcome to Spencer Trask Perspectives, a monthly interview series with our CEO Bill Clifford and writer John Essick. Mr. Clifford has generously agreed to share his unique insights and expert opinions on topics such as business development, deal flow, C-suite management, startup culture, entrepreneurialism, and more.

We welcome your feedback, and encourage you to submit questions to askST@spencertraskco.com for Mr. Clifford to answer in future articles.

It seems that finding a clear and concise definition of business development is a little like that old parable about the blind men and the elephant, with the meaning of the term depending upon…

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